OPEN ACCESS | Published on : 05-May-2026 | Pages: 1-95 | Doi : 10.37446/978-81-993853-1-3
Solubility Measurement, Thermodynamic Modelling, and Solvent Effects of Pharmaceutical and Chemical Compounds represents the first systematic, cross-disciplinary review to bring together solid–liquid equilibrium data from over 296 peer-reviewed articles published between 2012 and 2026. The compounds covered span an extraordinary breadth active pharmaceutical ingredients and drug candidates, natural products and phytochemicals, organic acids and industrial intermediates, agrochemicals, energetic materials, and sugars and amino acids united by the common thread of rigorous solubility characterisation. This breadth is intentional. Solubility science does not belong to any single discipline; the thermodynamic principles governing the dissolution of a fluoroquinolone antibiotic are the same as those governing a monomeric industrial acid or an energetic propellant precursor, and cross-disciplinary synthesis reveals patterns and insights that siloed reviews cannot.
The book is structured to serve readers at multiple levels of engagement. Those seeking experimental guidance will find a detailed treatment of all major measurement methods gravimetric shake-flask, laser dynamic polythermal, HPLC-based quantification, UV-Vis spectrophotometry, and visual synthetic approaches with critical assessment of their respective strengths, limitations, and uncertainty. Those requiring thermodynamic modelling tools will find rigorous, practically oriented coverage of the modified Apelblat equation, Buchowski–Ksiazaczak λh model, van't Hoff equation, Wilson, NRTL, and UNIQUAC activity coefficient models, and the full suite of binary solvent cosolvency models, accompanied by performance benchmarks derived from the entire reviewed dataset and concrete guidance on model selection. Those interested in the physical chemistry of solutions will find a comprehensive thermodynamic analysis of dissolution enthalpy, entropy, and Gibbs free energy across compound classes, including the phenomenon of enthalpy–entropy compensation, the role of hydrogen bonding and solvent cohesion in governing solubility order, and the application of KAT-LSER and Hansen solubility parameter frameworks.
The intended audience is broad. Pharmaceutical scientists involved in pre formulation, formulation development, and process chemistry will find the pharmaceutical compound coverage and thermodynamic framework directly applicable to their work. Chemical engineers designing crystallisation, purification, and separation processes will find the industrial compound data and binary solvent models of immediate practical relevance. Physical chemists and thermodynamicists will find the unified thermodynamic analysis and model comparison of theoretical interest. Graduate students and early-career researchers entering the field of solid–liquid equilibrium will find the experimental methods section and model selection guidance an accessible and thorough introduction. And experienced researchers in any of these areas will find the comprehensive reference tables and bibliography a time-saving and reliable resource for literature triage.
Solubility, Solid–liquid equilibrium, UV-Vis spectrophotometry, Van't Hoff equation
